A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Aspergillus Brain Abscess and Invasive Pulmonary Aspergillosis Successfully Treated with Voriconazole Followed by Cord Blood Transplantation.

January 1, 1970 Uncategorized

Gan To Kagaku Ryoho. 2019 Jul;46(7):1203-1209

Authors: Sekiguchi Y, Wakabayashi M, Takizawa H, Iizuka H, Sakajiri S, Sugimoto K, Inano T, Fukuda Y, Hamano Y, Tomita S, Izumi H, Okubo M, Nakamura N, Sawada T, Noguchi M

Abstract
A 59-year-old female was diagnosed as pulmonary aspergillosis(IPA)while remission induction therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia. Liposomal amphotericin B improved the fungal serodiagnostic markers, however,the IPA worsened. She also developed an Aspergillus brain abscess,which, while being undetectable on CT,was detected as multiple nodular lesions by MRI. A definitive diagnosis was made by polymerase chain reaction(PCR)of brain biopsy specimens. Voriconazole(VRCZ)was effective,and cord blood transplantation was performed. She has received VRCZ for a long time. There are no relapse of either the IPA or the Aspergillus brain abscess.

PMID: 31296832 [PubMed – in process]

Source: Industry