A new asymmetric diketopiperazine dimer from the sponge-associated fungus Aspergillus versicolor 16F-11.

A new asymmetric diketopiperazine dimer from the sponge-associated fungus Aspergillus versicolor 16F-11.

Magn Reson Chem. 2018 Jul 07;:

Authors: Gu BB, Gui YH, Liu L, Su ZY, Jiao WH, Li L, Sun F, Wang SP, Yang F, Lin HW

Abstract
A new asymmetric diketopiperazine dimer, Asperflocin (1), has been isolated from the fungus Aspergillus versicolor 16F-11. It’s structure was determined by virtue of detailed spectroscopic analysis, Marfey’s method, and 13 C NMR chemical shifts, [α]25D , and TDDFT/ECD calculations. Cytotoxic activity test showed that 1 has moderate cytotoxic activity against A375 cell line with IC50 value of 10.29 ± 2.37 μM.

PMID: 29981526 [PubMed – as supplied by publisher]

Source: Industry