Antiaflatoxigenic thiosemicarbazones as crop-protective agents: a cytotoxic and genotoxic study.
J Agric Food Chem. 2019 Sep 09;:
Authors: Bartoli J, Montalbano S, Spadola G, Rogolino D, Pelosi G, Bisceglie F, Restivo FM, Degola F, Serra O, Buschini A, Feretti D, Zani C, Carcelli M
Aflatoxins are secondary fungal metabolites that can contaminate feed and food. They are cause of growing concern worldwide, because they are potent carcinogenic agents. Thiosemicarbazones are molecules that possess interesting antiaflatoxigenic properties but, in order to use them as crop protective agents, their cytotoxic and genotoxic profiles must first be assessed. In this paper, a group of thiosemicarbazones and a copper complex are reported as compounds able to contrast aflatoxins biosynthesis, fungal growth, and sclerotia biogenesis in Aspergillus flavus. The two most interesting thiosemicarbazones found are non-cytotoxic on several cell lines (CRL1790, Hs27, HFL1, and U937), and therefore they were submitted to additional analysis of mutagenicity and genotoxicity on bacteria, plants and human cells. No mutagenic activity was observed in bacteria, while a genotoxic activity was revealed by the Alkaline Comet Assay on U937 cells and by the test of chromosomal aberrations in Allium cepa.
PMID: 31498626 [PubMed – as supplied by publisher]