Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258 Endophytic with the Medicinal and Edible Plant, Garcinia multiflora.

Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258 Endophytic with the Medicinal and Edible Plant, Garcinia multiflora.

J Agric Food Chem. 2019 Sep 03;:

Authors: Zhu W, Wang L, He W, Xu Y, Fu P, Zuo M, Liu W, Jiang Y

Abstract
Two new indolyl diketopiperazines, gartryprostatins A and B (1 and 2) with an unusual 2,3-furan fused pyrano[2,3-g]pyrrolo[1”,2”:4′,5′]pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole nucleus, along with a new naturally-occurring compound (gartryprostatin C, 3) were isolated from the solid culture of Aspergillus sp. GZWMJZ-258, an endophyte from Garcinia multiflora (Guttiferae). The structures of compounds 1-3 were determined by NMR, MS, Marfey’s analysis of amino acids and chemical calculation. Compounds 1-3 displayed a selective inhibition on human FLT-3 ITD-mutant AML cell line, MV4-11, with IC50 values of 7.2, 10.0 and 0.22 ┬ÁM, respectively.

PMID: 31479263 [PubMed – as supplied by publisher]

Source: Industry