Cytotoxic p-terphenyls from the deep-sea-derived Aspergillus candidus.
Nat Prod Res. 2019 Jun 24;:1-5
Authors: Lin YK, Xie CL, Xing CP, Wang BQ, Tian XX, Xia JM, Jia LY, Pan YN, Yang XW
From the deep-sea-derived fungus Aspergillus candidus, one novel (1) and three known (2-4) p-terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor bioactivities. Compounds 3 and 4 showed potent antiproliferative effect against four cancer cells of Hela, Eca-109, Bel-7402, and PANC-1 with IC50 values ranging from 5.5 μM to 9.4 μM.
PMID: 31232100 [PubMed – as supplied by publisher]