Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.

Org Biomol Chem. 2018 Jun 27;:

Authors: Lin H, Lyu H, Zhou S, Yu J, Keller NP, Chen L, Yin WB

Abstract
By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.

PMID: 29947411 [PubMed – as supplied by publisher]

Source: Industry