Development of Allergic Bronchopulmonary Aspergillosis in a Patient with Crohn’s Disease.
Intern Med. 2019 Jun 27;:
Authors: Sasaki H, Miyata J, Maki Y, Kimizuka Y, Hayashi N, Fujikura Y, Kawana A
Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn’s disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.
PMID: 31243216 [PubMed – as supplied by publisher]