Early necrotic skin lesions after an ABO-incompatible kidney transplantation: the threat of Cunninghamella Spp.

Early necrotic skin lesions after an ABO-incompatible kidney transplantation: the threat of Cunninghamella Spp.

Transpl Infect Dis. 2019 Sep 16;:e13173

Authors: Belliere J, Rolland M, Tournier E, Cassaing S, Iriart X, Paul C, Kamar N

Abstract
A 49-year-old man underwent ABO-incompatible kidney transplantation with a living donor. At day 33 post-transplantation, he presented with undiagnosed epilepsy with generalized tonic-clonic seizures. At day 44 post-transplantation, he developed left-sided pneumonia attributed to Aspergillus fumigatus and treatment with liposomal Amphotericin B was initiated. At day 51 post-transplantation, necrotic skin lesions appeared. DNA sequencing in a fresh cutaneous biopsy finally identified Cunninghamella Spp., a member of the order Mucorales. Unfortunately, the necrotic lesions spread, and the patient died at day 60 post-transplantation. This case report highlights the infectious risk related to ABO-incompatible kidney transplantation and suggests a requirement for rapid identification of every skin lesion, even in the early phases of immunosuppression.

PMID: 31529558 [PubMed – as supplied by publisher]

Source: Industry