Elevated serum levels of periostin in patients with Allergic Bronchopulmonary Aspergillosis.

Elevated serum levels of periostin in patients with Allergic Bronchopulmonary Aspergillosis.

Mycoses. 2019 Jun 07;:

Authors: Wu G, Meng X, Zheng P, Zhang XHD, Li L, Hu H, Sun B

Abstract
BACKGROUND: Serum periostin levels have been reported to be an indicator of Th2 inflammation in asthmatic patients.
OBJECTIVE: This study aimed to investigate serum levels of periostin in patients with Allergic bronchopulmonary aspergillosis (ABPA) and to evaluate its diagnostic and monitoring value in the disease.
METHODS: Patients with ABPA (n=19) and asthma (n=24), including severe asthma with fungal sensitization (SAFS, n=11) and severe asthma without fungal sensitization (SAwFS, n=13), were enrolled. Serum levels of periostin were analyzed by Enzyme-linked immunosorbent assay. Serum total IgE and Aspergillus fumigatus specific IgE, IgG were measured by ImmunoCAP. Levels of cytokines (IFN-γ, IL-4, IL-5, IL-8, IL-10, IL-13 and IL-17A) were measured by Meso Scale Discovery (MSD).
RESULTS: Serum levels of periostin in ABPA patients (85.55 ng/mL, [68.28-166] ng/mL) were higher than those in SAFS (50.99 ng/mL, [32.02-71.80] ng/mL) (p<0.01). Among the analyzed cytokines, IL-5 levels in ABPA (1.55 pg/mL, [0.96-3.33] pg/mL) were higher than those in SAFS (0.31 pg/mL, [0.26-0.56] pg/mL) (p<0.05) or SAwFS (0.34 pg/mL, [0.21-0.56] pg/mL) (p<0.01). Serum periostin levels was positively associated with total IgE levels (r=0.319, p<0.05), serum IL-5 levels (r=0.484, p<0.01) and blood eosinophil counts (r=0.428, p<0.05). In ROC analysis, the clinical reference value of periostin was 68.8 ng/mL for differential diagnosis of ABPA and SAFS, with the areas under the curves (AUC) of 0.81. Longitudinally, serum periostin levels did not change significantly after treatment in ABPA.
CONCLUSIONS: These findings suggested that serum levels of periostin were up-regulated in ABPA patients, which may be associated with eosinophilic inflammation. This article is protected by copyright. All rights reserved.

PMID: 31173398 [PubMed – as supplied by publisher]

Source: Industry