Fungus Among Us: The Frenemies Within.
Trends Immunol. 2019 Apr 30;:
Authors: Aggor FEY, Way SS, Gaffen SL
A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human CD4+ Th17 cells that harbor heterologous specificity for other fungi, which may explain evolutionary benefits of C. albicans as a commensal microbe (Bacher et al. Cell 2019;176;1340-1355). However, Th17 cells that are crossreactive to Aspergillus fumigatus antigens can also drive exaggerated airway inflammation in humans.
PMID: 31053496 [PubMed – as supplied by publisher]