Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Emerg Infect Dis. 2019 Sep;25(9):1778-1779

Authors: Bellanger AP, Berceanu A, Scherer E, Desbrosses Y, Daguindau E, Rocchi S, Millon L

Abstract
We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.

PMID: 31441760 [PubMed – in process]

Source: Industry