Mixed mold pulmonary infections in hematological cancer patients in a tertiary care cancer center.
Mycoses. 2018 Jul 17;:
Authors: Magira EE, Jiang Y, Economides M, Tarrand J, Kontoyiannis DP
There is a paucity of data regarding mixed mold pulmonary infections (MMPIs) in patients with hematologic malignancies with or without hematopoietic stem cell transplantation (HSCT). We retrospectively studied 27 such patients (2005-2015) and compared them to patients with invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus. Factors associated with the diagnosis of MMPIs were significant corticosteroid use [20(74%) vs 6(22%), p<0.001], sputum as the source specimen [13(48%) vs 3(11%), p=0.003], younger age (median age: 58 vs 66 years, p=0.006), and male sex [22(81%) vs 13(48%), p=0.01]. Hematologic cancers other than acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS) were less common in MMPIs than in IPA patients [AML/MDS: 6(22%) vs 14(52%), p=0.04]. Only significant corticosteroid use [95% CI (2.7-42.7), p<0.001], and sputum as the source specimen [95% (1.6-41.6), p=0.012] were statistically significant as independently associated with increased risk of MMPIs diagnosis in multivariate analysis. Total mortality rate at day 42 post diagnosis was comparable in both groups. This article is protected by copyright. All rights reserved.
PMID: 30015364 [PubMed – as supplied by publisher]