New monoterpenoid by biotransformation of thymoquinone using Aspergillus niger.
Bioorg Chem. 2018 Jun 12;80:212-215
Authors: Mohammad MY, Shakya A, Al-Bakain R, Haroon MH, Choudhary MI
Microbial transformation of thymoquinone (5-isopropyl-2-methyl-cyclohexa-2,5-diene-1,4-dione) (1) by suspended cell-cultures of the plant pathogenic fungus Aspergillus niger resulted in the production of three metabolites. These metabolites were identified as 5-isopropyl-2-methyloxepin-1-one (2), 3-hydroxy-5-isopropyl-2-methylcyclohexa-2,5-diene-1,4-dione (3), and 5-isopropyl-2-methylbenzene-1,4-diol (4) by different spectroscopic methods. Metabolite 2 was found to be a new compound. Compound 4 showed a potent antioxidant activity.
PMID: 29957489 [PubMed – as supplied by publisher]