Pentraxin3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis.

Pentraxin3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis.

Clin Microbiol Infect. 2018 Jun 28;:

Authors: Li H, Liu L, Zhou W, Rui Y, He B, Shi Y, Su X

Abstract
OBJECTIVES: Pentraxin 3 (PTX3) contributes to resistance to Aspergillus infections, this study aimed to evaluate the presence of PTX3 in bronchoalveolar lavage fluid (BALF) and plasma in non-neutropenic patients with pulmonary aspergillosis.
METHODS: BALF (n=211) and plasma samples (n=307) were collected from patients initially suspected of having pulmonary aspergillosis. Among these, 112 cases were proven to be pulmonary aspergillosis (51BALF samples and 89plasma samples). These cases were classified as invasive pulmonary aspergillosis (IPA), sub-acute invasive aspergillosis (SAIA) and chronic pulmonary aspergillosis (CPA). The remaining cases were non-aspergillosis controls and were diagnosed with community-acquired pneumonia (CAP), lung cancer and pulmonary cryptococcosis. Plasma samples from healthy controls (n=30) were also collected.
RESULTS: The median [interquartile range (IQR)] BALF PTX3 for aspergillosis cases was significantly higher than for non-aspergillosis (6.97[2.91-13.51]ng/ml vs. 1.26[0.76-1.76]ng/ml). When the PTX3 threshold was set at 1.9ng/ml, sensitivity and specificity of BALF PTX3 for aspergillosis were 86.3% (95% confidence interval CI 83.8%-88.4%) and 82.5%(95% CI 79.7%-85.0%), respectively. The median [IQR] plasma PTX3 for aspergillosis was significantly higher than for non-aspergillosis cases and healthy controls (7.10[3.36-9.53]ng/ml vs. 1.57[0.86-2.35]ng/ml vs. 1.10[0.49-1.51]ng/ml). With a PTX3 threshold of 2.3ng/ml, sensitivity and specificity were 79.8% (95% CI 70.1%-81.2%) and 72.1% (95% CI 69.5%-74.5%) respectively.
CONCLUSIONS: BALF and plasma PTX3 may be biomarkers for differentiating aspergillosis from other conditions, such as CAP, lung cancer, and pulmonary cryptococcosis in non-neutropenic patients.

PMID: 29964232 [PubMed – as supplied by publisher]

Source: Industry