Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi.

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Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi.

Org Biomol Chem. 2019 May 14;:

Authors: Kaneko A, Morishita Y, Tsukada K, Taniguchi T, Asai T

Abstract
Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 gene. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkylresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via a type III PKS in fungi.

PMID: 31086874 [PubMed – as supplied by publisher]

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