Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina.

Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina.

J Antibiot (Tokyo). 2018 Jun 08;:

Authors: Afiyatullov SS, Zhuravleva OI, Antonov AS, Berdyshev DV, Pivkin MV, Denisenko VA, Popov RS, Gerasimenko AV, von Amsberg G, Dyshlovoy SA, Leshchenko EV, Yurchenko AN

Abstract
Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.

PMID: 29884864 [PubMed – as supplied by publisher]

Source: Industry