Two New Phytoecdysteroids From Sphenocentrum jollyanum Pierre Root.

Two New Phytoecdysteroids From Sphenocentrum jollyanum Pierre Root.

Steroids. 2019 Jul 18;:108456

Authors: Ajayi TO, Srivedavyasasri R, Nyong EE, Odeniyi MA, Moody JO, Ross SA

Abstract
The crude methanol extract of Sphenocentrum jollyanum root exhibited 98% and 80% antimicrobial activity against Aspergillus fumigatus Pinh and Vancomycin resistant enterococcus (VRE) at a concentration of 200 µg/mL, with IC50 11.45 and 12.95 µg/mL, respectively. The ethyl acetate fraction of methanol extract showed in-vitro antimicrobial activity against A. fumigatus Pinh at 83% with IC50 of <8 µg/mL. The phytochemical investigation of ethyl acetate fraction yielded six compounds, which were identified by their NMR, IR and MS spectral analyses as two new phytoecdysteroidal glycosides Sphenocentroside A (1), and Sphenocentroside B (2), and four known phytoecdysteroids: polypodoaurein (3), polypodine B (4), ecdysterone (5), and 20, 26-dihydroxyecdysone (6).

PMID: 31326452 [PubMed – as supplied by publisher]

Source: Industry