Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT).
Org Biomol Chem. 2019 Nov 20;:
Authors: Xu K, Yang C, Xu Y, Li D, Bao S, Zou Z, Kang F, Tan G, Li SM, Yu X
Prenylation increases the bioactivity of flavonoids. Herein, we report the first examples of regioselective enzymatic geranylation of biflavonoids using Aspergillus terreus aromatic prenyltransferase (AtaPT). For biflavonoids 1-3 dimerized through a diphenyl linkage, geranylation occurs at the hydrogen bond involving C5”-OH group, which is less chemically accessible than other OH groups in the molecule. This study would be referential for developing green synthetic solutions for prenylated biflavonoids.
PMID: 31746920 [PubMed – as supplied by publisher]