Antibacterial Diphenyl ether, benzophenone and xanthone derivates from Aspergillus flavipes.
Chem Biodivers. 2019 Dec 05;:
Authors: Ji YB, Chen WJ, Shan TZ, Sun BY, Yan PC, Jiang W
The extract of the strain Aspergillus flavipes DL-11 exerted antibacterial activities against six Gram-positive bacteria. During the following bioassay-guided separation, ten diphenyl ethers ( 1 – 10 ), two benzophenones ( 11 – 12 ), together with two xanthones ( 13 – 14 ) were isolated. Among them, 4′-chloroasterric acid ( 1) was a new chlorinated diphenyl ether. Their structures were elucidated by extensive spectroscopic data analysis, including IR, HRESIMS, NMR experiments, and by comparison with the literature data. All compounds showed moderate to strong antibacterial effects on different Gram-positive bacteria with MIC values that ranged from 3.13 to 50 μ g/mL, but none of the compounds exhibited activity against Gram-negative bacteria Vibrio parahemolyticus ATCC17802 (MIC >100 μ g/mL). In particular, the MICs of some compounds are at the level of positive control.
PMID: 31805214 [PubMed – as supplied by publisher]