Quinoline based monocarbonyl curcumin analogues as potential antifungal and antioxidant agents: Synthesis, Bioevaluation and molecular docking study.

Quinoline based monocarbonyl curcumin analogues as potential antifungal and antioxidant agents: Synthesis, Bioevaluation and molecular docking study.

Chem Biodivers. 2019 Dec 21;:

Authors: Nagargoje AA, Akolkar SV, Siddiqui MM, Subhedar DD, Sangshetti JN, Khedkar VM, Shingate BB

Abstract
In search of new fungicidal and free radical scavenging agents, we synthesized a focused library of 2-chloroquinoline based monocarbonyl analogues of curcumin (MACs). The synthesized MACs were evaluated for in vitro antifungal and antioxidant activity. The antifungal activity was evaluated against five different fungal strains such as Candida albicans , Fusarium oxysporum , Aspergillus flavus , Aspergillus Niger , Cryptococcus neoformans respectively. Most of the synthesized MACs displayed promising antifungal activity as compared to standard drug Miconazole. Furthermore, molecular docking study on a crucial fungal enzyme sterol 14α-demethylase (CYP51) could provide insight into the plausible mechanism of antifungal activity. Also, MACs were screened for in vitro radical scavenging activity using butylated hydroxyl toluene (BHT) as a standard. Almost all MACs exhibited better antioxidant activity as compared to BHT.

PMID: 31863703 [PubMed – as supplied by publisher]

Source: Industry