Structurally Diverse Meroterpenoids from a Marine-Derived Aspergillus sp. Fungus.

Structurally Diverse Meroterpenoids from a Marine-Derived Aspergillus sp. Fungus.

J Nat Prod. 2019 Dec 23;:

Authors: Wen H, Yang X, Liu Q, Li S, Li Q, Zang Y, Chen C, Wang J, Zhu H, Zhang Y

Abstract
Three new meroterpenoids, asperaustins A-C (1-3), and seven known analogues (4-10) were isolated from a marine-derived Aspergillus sp. fungus. The structures and absolute configurations of these new compounds were unequivocally determined by extensive spectroscopic analyses and single-crystal X-ray diffraction analyses. Asperaustin A (1) possesses an unusual spiro[4.5]deca-3,6-dien-2-one moiety with a unique 5/6/6/6/5 pentacyclic skeleton. The absolute configurations of austinoneol A (7) and precalidodehydroaustin (9) were determined by single-crystal X-ray diffraction analyses using Cu Kα radiation for the first time.

PMID: 31867967 [PubMed – as supplied by publisher]

Source: Industry