Acute lung injury and repair induced by single exposure of Aspergillus fumigatus in immunocompetent mice.

Acute lung injury and repair induced by single exposure of Aspergillus fumigatus in immunocompetent mice.

Future Microbiol. 2020 Jan 08;:

Authors: Malacco NL, Souza JA, Mendes AC, Rachid MA, Kraemer LR, Mattos MS, Lima GN, Sousa LP, Souza DG, Pinho V, Teixeira MM, Russo RC, Soriani FM

Abstract
Aim: Characterize the course of acute Aspergillus fumigatus lung infection in immunocompetent mice, investigating the immunological, pathological and tissue functional modifications. Materials & methods: C57BL/6 mice were intranasally infected with A. fumigatus conidia and euthanized to access inflammatory parameters. Results: Mice infected with A. fumigatus showed an inoculum-dependent lethality and body weight loss. An intense proinflammatory cytokine release, neutrophil infiltrate and pulmonary dysfunction was also observed in the early phase of infection. In the late phase of infection, proresolving mediators release, apoptosis and efferocytosis increased and lung tissue architecture is restored. Conclusion: Our study characterized an immunocompetent model of acute pulmonary Aspergillus infection in mice and opened an array of possibilities for investigations on interactions of A. fumigatus with host-immune system.

PMID: 31913059 [PubMed – as supplied by publisher]

Source: Industry