Identification of repositionable drugs with novel antimycotic activity by screening Prestwick Chemical Library against emerging invasive molds.

Identification of repositionable drugs with novel antimycotic activity by screening Prestwick Chemical Library against emerging invasive molds.

J Glob Antimicrob Resist. 2020 Jan 28;:

Authors: Yousfi H, Ranque S, Cassagne C, Rolain JM, Bittar F

Abstract
The incidence of severe filamentous fungi infections has increased over the past decade. Some of these filamentous fungi are resistant to available antifungals; it is thus urgent to find new compounds that are active against such life-threatening pathogens. Here, 1280 drugs (Prestwick Chemical Library) were tested against six multidrug-resistant filamentous fungi including, Aspergillus, Fusarium, Scedosporium, Rhizopus and Lichtheimia species. We identified several hits that induce fungal growth inhibition ≥ 70%. Clioquinol, alexidine dihydrochloride, hexachlorophene and thonzonium bromide, displayed a broad activity against all strains tested. This study enriches the potential antifungal options that can be used against multidrug-resistant invasive fungal diseases.

PMID: 32004725 [PubMed – as supplied by publisher]

Source: Industry