Aspergillus niger α-1,3-glucan acts as a virulence factor by inhibiting the insect phenoloxidase system.

Aspergillus niger α-1,3-glucan acts as a virulence factor by inhibiting the insect phenoloxidase system.

J Invertebr Pathol. 2020 Feb 10;:107341

Authors: Stączek S, Zdybicka-Barabas A, Pleszczyńska M, Wiater A, Cytryńska M

Abstract
Phenoloxidase (PO) is a key enzyme in the melanization process involved in elimination of pathogens in insects. The PO system is rapidly activated in response to pathogen recognition. Inhibition of PO activity can be a way to avoid immune response and increase infection effectiveness. In this study, the effects of inoculation of Galleria mellonella larvae with Aspergillus niger α-1,3-glucan and conidia on PO activity in hemolymph are analyzed in comparison with the effects of β-1,3/1,6-glucan inoculation. Our results indicate that α-1,3-glucan, a fungal cell wall polysaccharide, can play a role of a virulence factor involved in inhibition of the insect PO system.

PMID: 32057750 [PubMed – as supplied by publisher]

Source: Industry