Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan1.
Emerg Infect Dis. 2020 Apr;26(4):804-806
Authors: Wu CJ, Liu WL, Lai CC, Chao CM, Ko WC, Wang HC, Dai CT, Hsieh MI, Choi PC, Yang JL, Chen YC
In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.
PMID: 32186508 [PubMed – as supplied by publisher]