Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma.

Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma.

Clin Exp Allergy. 2020 Jun 08;:

Authors: Wardlaw A, Howarth PH, Israel E, Taillé C, Quirce S, Mallett S, Bates S, Albers FC, Kwon N

Abstract
In asthma, sensitization to fungal, perennial or seasonal allergens increases the risk of uncontrolled symptoms, exacerbations, and poor disease outcomes.In severe asthma, typically 20%-29% of patients show sensitization to ≥1 fungal allergen, with Aspergillus being one of the most common.These patients have worse lung function, increased risk of oral corticosteroid use, hospitalization, and a greater degree of airflow obstruction than patients non-sensitized to fungal allergens.

PMID: 32515118 [PubMed – as supplied by publisher]

Source: Industry