Fungal Melanin Rewires Macrophage Metabolism.
Trends Biochem Sci. 2020 Jul 01;:
Authors: Papon N, Gangneux JP, Delneste Y
Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.
PMID: 32622750 [PubMed – as supplied by publisher]