Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.

Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.

Rev Soc Bras Med Trop. 2020;53:e20200401

Authors: Santana MF, Pivoto G, Alexandre MAA, BaĆ­a-da-Silva DC, Borba MGDS, Val FA, Brito-Sousa JD, Melo GC, Monteiro WM, Souza JVB, Pinheiro SB, Ferreira LCL, Naveca FG, Nascimento VA, Corado ALG, Hajjar LA, Silva Neto JR, Siva GAV, Pasqualotto AC, Lacerda MVG

Abstract
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.

PMID: 32638890 [PubMed – in process]

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