Azole resistance in environmental Aspergillus fumigatus isolates from China: A five-year survey from 2014 to 2018.

Azole resistance in environmental Aspergillus fumigatus isolates from China: A five-year survey from 2014 to 2018.

Antimicrob Agents Chemother. 2020 Jul 27;:

Authors: Cao D, Wu R, Dong S, Wang F, Ju C, Yu S, Xu S, Fang H, Yu Y

Abstract
A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples.

PMID: 32718960 [PubMed – as supplied by publisher]

Source: Industry