Soluble Intercellular Adhesion Molecule (ICAM)-1 detects invasive fungal infections in patients following liver transplantation.

Soluble Intercellular Adhesion Molecule (ICAM)-1 detects invasive fungal infections in patients following liver transplantation.

Biomarkers. 2020 Aug 17;:1-28

Authors: Decker SO, Incamps A, Wilk H, Uhle F, Bruckner T, Heininger A, Zimmermann S, Mehrabi A, Mieth M, Weiss KH, Weigand MA, Brenner T

Abstract
Purpose: Despite antifungal prophylaxis, liver transplanted patients are endangered by invasive fungal infections (IFI). Routinely used microbiological procedures are hallmarked by significant weaknesses, which may lead to a delay in antifungal treatment.Methods: Culture-based fungal findings, routinely used biomarkers of infection/inflammation (e.g. procalcitonin or C-reactive protein), as well as corresponding plasma concentrations of soluble Intercellular Adhesion Molecule (ICAM)-1 were analysed in 93 patients during a period of 28 days following liver transplantation (LTX).Results: Plasmatic sICAM-1 was significantly elevated in patients affected by an IFI within the first 28 days in comparison to fungally colonized or unobtrusive LTX patients. sICAM-1 might therefore be helpful for the identification of IFI patients after LTX (e.g. Receiver Operating Characteristic (ROC)-Area Under the Curve (AUC): 0.714 at 14d after LTX). The diagnostic performance of sICAM-1 was further improved by its combined use with different other IFI biomarkers (e.g. midregional proadrenomedullin).Conclusion: The diagnostic deficiencies of routinely used microbiological procedures for IFI detection in patients after LTX may be reduced by plasmatic sICAM-1 measurements.Clinical Trial Notation. German Clinical Trials Register: DRKS00005480.

PMID: 32803993 [PubMed – as supplied by publisher]

Source: Industry