New naphthyl derivatives from Aspergillus californicus.

New naphthyl derivatives from Aspergillus californicus.

J Antibiot (Tokyo). 2020 Oct 01;:

Authors: Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO

Abstract
Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml-1) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC50 values of 18 and 24 µg·ml-1, respectively.

PMID: 32999431 [PubMed – as supplied by publisher]

Source: Industry