Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus.

Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus.

Org Lett. 2020 Oct 02;:

Authors: Zheng L, Yang Y, Wang H, Fan A, Zhang L, Li SM

Abstract
A highly oxygenated phenethyl derivative ustethylin A was isolated from Aspergillus ustus. Gene deletion, isotope labeling, and heterologous expression proved that the phenethyl core structure is assembled from malonyl-CoA by a polyketide synthase harboring a methyltransferase domain. Propionate was converted via acetyl-CoA to malonyl-CoA and incorporated into the molecule. Modifications on the core structure by three different oxidoreductases and one O-methyltransferase lead to the final product, ustethylin A.

PMID: 33006285 [PubMed – as supplied by publisher]

Source: Industry