One new piperazinedione isolated from a mangrove-derived fungus Aspergillus niger JX-5.
Nat Prod Res. 2020 Oct 04;:1-7
Authors: Bai M, Wang Y, Liu T, Lian YX, Bai QQ, Song XP, Han CR, Zheng CJ, Chen GY
One new piperazinedione derivative, nigerpiperazine A (1), along with six known compounds (2-7) were isolated from the fungus Aspergillus niger JX-5 from mangrove Ceriops tagal. Nigerpiperazine A (1) was elucidated by spectroscopic analyses and 13C NMR chemical shift calculations, compounds 4 and 5 were determined by X-ray and the CD spectra. The absolute configuration of 4 was identified by X-ray for the first time. Compounds 1 and 4 showed inhibitory activities against Helicoverpa armigera Hubner with the IC50 values of 200 and 100 µg/mL, respectively.
PMID: 33016123 [PubMed – as supplied by publisher]