Asperochratides A-J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus.
Bioorg Chem. 2020 Oct 08;105:104349
Authors: Zou ZB, Zhang G, Li SM, He ZH, Yan QX, Lin YK, Xie CL, Xia JM, Luo ZH, Luo LZ, Yang XW
Ten new C9 polyketides (asperochratides A-J, 1-10) and 14 known miscellaneous compounds (11-24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher’s method, Mo2(OAc)4 induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1-11 and 16-18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5-8 and 13-17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.
PMID: 33074115 [PubMed – as supplied by publisher]