Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029.
J Antibiot (Tokyo). 2020 Oct 27;:
Authors: Chen W, Chen C, Long J, Lan S, Lin X, Liao S, Yang B, Zhou X, Wang J, Liu Y
Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml-1, respectively.
PMID: 33106626 [PubMed – as supplied by publisher]