Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus.

Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus.

Nat Prod Res. 2020 Nov 09;:1-6

Authors: Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO

Abstract
A chemical investigation of Aspergillus californicus IBT 16748 led to the isolation of two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides oxepinamides L (1) and M (2). Their structures were characterised by spectroscopic analysis including HRESIMS, 1D and 2D NMR. The absolute structure of 1 was assigned by ECD calculation. The antibacterial and cytotoxic properties of 1 were evaluated.

PMID: 33161768 [PubMed – as supplied by publisher]

Source: Industry