Sensitization to A.fumigatus in subjects with non-cystic fibrosis bronchiectasis.
Mycoses. 2020 Dec 17;:
Authors: Sehgal IS, Dhooria S, Prasad KT, Muthu V, Aggarwal AN, Rawat A, Pal A, Bal A, Garg M, Chakrabarti A, Agarwal R
BACKGROUND: Patients with chronic lung diseases, including cystic fibrosis (CF), are frequently sensitized to Aspergillus fumigatus. Whether patients with non-CF bronchiectasis develop sensitization to A.fumigatus remains unknown.
OBJECTIVE: To evaluate the prevalence of sensitization and chronic infection with A.fumigatus in subjects with bronchiectasis. We also performed a multivariate logistic regression analysis to identify factors predicting sensitization and chronic A.fumigatus infection.
METHODS: Subjects with bronchiectasis were investigated with serum A.fumigatus-specific IgE and IgG, and sputum cultures for bacteria, fungus, and mycobacteria. We defined A.fumigatus sensitization and chronic A.fumigatus infection as serum A.fumigatus-specific IgE and IgG >0.35 kUA/L and >27 mgA/L, respectively. We excluded subjects with bronchiectasis secondary to allergic bronchopulmonary aspergillosis.
RESULTS: We included 258 subjects (TB [n=155], idiopathic [n=66] and other causes [n=37]) with bronchiectasis. The prevalence of Aspergillus sensitization, chronic Aspergillus infection, and both sensitization and chronic infection was 29.5% (76/258), 76% (196/258), and 26% (68/258), respectively. In a multivariate logistic regression analysis, TB-related bronchiectasis was an independent risk factor for Aspergillus sensitization. Chronic Aspergillus infection was predicted by the duration of symptoms and specific etiologies (tuberculosis and idiopathic) of bronchiectasis. The growth of Aspergillus species was also frequent in the TB group compared to other causes (32% vs. 2%; p<0.001).
CONCLUSIONS: We found a significant occurrence of Aspergillus sensitization and chronic infection in non-CF bronchiectasis, especially in TB-bronchiectasis. In addition to Aspergillus sensitization, investigations for chronic Aspergillus infection should be routinely performed in non-CF bronchiectasis, both at diagnosis and during followup.
PMID: 33332671 [PubMed – as supplied by publisher]