p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and alpha-Glycosidase Inhibitory Activities

Front Microbiol. 2021 Feb 25;12:654963. doi: 10.3389/fmicb.2021.654963. eCollection 2021.


One new (1) and fifteen known (216) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (1725) were synthesized from the main compounds (57), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 were also, respectively, synthesized from compounds 6 and 7 by oxidative cyclization of air in the presence of silica gel. These p-terphenyls especially those with 4,2′,4″-trihydroxy (47, 20, 21) or 4, 4″-dihydroxy-1,2,1′,2′-furan (15, 16) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.

PMID:33717048 | PMC:PMC7947296 | DOI:10.3389/fmicb.2021.654963

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