Genome Mining-Driven Discovery of 5-Methylorsellinate-Derived Meroterpenoids from Aspergillus funiculosus

Org Lett. 2021 Apr 6. doi: 10.1021/acs.orglett.1c00951. Online ahead of print.


Heterologous expression of a cryptic gene cluster in the fungus Aspergillus funiculosus CBS 116.56 led to the discovery of four new meroterpenoids, funiculolides A-D (14), derived from the aromatic polyketide 5-methylorsellinic acid (5-MOA). Intriguingly, funiculolide D (4), the apparent end product of the pathway, harbors an unusual spirocyclopentanone moiety, which is synthesized by the oxidative rearrangement catalyzed by the ferrous iron and α-ketoglutarate-dependent dioxygenase FncG.

PMID:33821662 | DOI:10.1021/acs.orglett.1c00951

Source: Industry