A fatal case of COVID-19-associated invasive pulmonary aspergillosis

J Infect Chemother. 2021 Apr 1:S1341-321X(21)00105-7. doi: 10.1016/j.jiac.2021.03.024. Online ahead of print.

ABSTRACT

A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.

PMID:33867266 | DOI:10.1016/j.jiac.2021.03.024