Unveiling the dermatological potential of marine fungal species components: Antioxidant and inhibitory capacities over tyrosinase
Biotechnol Appl Biochem. 2021 May 24. doi: 10.1002/bab.2201. Online ahead of print.
Marine fungi are rich source of biologically active molecules; but, a poorly explored bioresource for cosmeceutical products. This study evaluates the phytochemistry, antioxidant, and anti-tyrosinase effects of the organic extracts of marine fungi isolated from various marine environments in India. Out of 35 screened fungal strains, methanol extracts of strains P2, Talaromyces stipitatus and D4, Aspergillus terreus exhibited anti-tyrosinase activity of 45% and 43% respectively at the lowest concentration of 0.5 mg/mL. Highest free radicals scavenging activity of 94% and 97% was observed at 500 mg/mL respectively of same fungal extracts.Total phenolic content ranged from 8.20 to 20.30 mg/g of dry weight of extract, expressed as gallic acid equivalent. GC-MS analysis of Talaromyces stipitatus and Aspergillus terreus extract identified 07 and 10 major compounds, respectively. Some of themajor compounds included Azetidine, (3E)-3-[(3,5-Dimethoxybenzoyl) hydrazono]-N-isobutyl butanamide, aziridine and 3-Methylcyclopentanone, 1,1-Dimethylcyclohexane, Cyclopentane carboxylic acid, N-Allyl-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxamide, cyclo(L-Pro-L-Val) and 3-Phenylpropionitrile. In conclusion, this study showed abundant fungal resources in Indian marine environments. A correlation between total phenolic contents of the extracts confirmed that phenolic compounds play an important role in antioxidant as well as antityrosinase activity of the marine fungal extracts and can be viewed as new potential anti-tyrosinase and antioxidant resources. This article is protected by copyright. All rights reserved.