Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029

Nat Prod Res. 2021 Aug;35(16):2647-2654. doi: 10.1080/14786419.2019.1660331. Epub 2019 Sep 6.

ABSTRACT

During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain Aspergillus fumigatus MF029 exhibited moderate bioactivities against Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, and Mycobacterium bovis bacillus Calmette-Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A (1) and sphingofungin I (2), together with four known compounds, emodin (3), chaetominine (4), sphingofungin D (5) and trypacidin (6). Trypacidin displayed potential antitubercular activity with MIC value of 1.25 μg/mL.

PMID:34414849 | DOI:10.1080/14786419.2019.1660331