Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Transl Cancer Res. 2021 Feb;10(2):1169-1176. doi: 10.21037/tcr-20-2434.

ABSTRACT

Pulmonary sequestration is a rare congenital dysplasia, and intralobar pulmonary sequestration was caused by aspergillus infection are more uncommon. The significant increase of serum CA19-9 and CA242 often indicates malignant tumors of the pancreas, biliary tract and gastrointestinal tract, but it is different in this case we reported. We present a case of a 36-year-old woman with intralobar pulmonary sequestration with aspergillus infection and elevated serum tumor markers CA19-9 and CA242. The patient had a right lung occupying lesion on the chest CT and sulfur particles are formed in the lesioned bronchial lumen. According to the results of the imaging and pathological, and serum CA19-9 and CA242 increased significantly, it was initially suspected to be a malignant tumor, so the right lobectomy and lymph node dissection were performed. Postoperative pathological examination confirmed intralobar pulmonary sequestration with aspergillus infection. After 22 days of surgery, the level of serum CA19-9 and CA242 were significantly decreased and gradually decreased to normal. This is a rare case of pulmonary sequestration accompanied by aspergillus infection in which serum CA19-9 and CA242 are elevated; it’s also the first report that pulmonary sequestration accompanied by aspergillus infection with sulfur particles formation. It is suggested that patients with pulmonary sequestration, especially those complicated with aspergillus infection, may be accompanied by elevated serum tumor markers CA19-9 and CA242, which should not be misdiagnosed as malignant tumors.

PMID:35116444 | PMC:PMC8799253 | DOI:10.21037/tcr-20-2434

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