A new butenolide with antifungal activity from solid co-cultivation of <em>Irpex lacteus</em> and <em>Nigrospora oryzae</em>

Nat Prod Res. 2022 Feb 11:1-5. doi: 10.1080/14786419.2022.2037589. Online ahead of print.

ABSTRACT

A new antifungal butenolide irperide (1) along with five known compounds were isolated from the co-culture of endophyte Irpex lacteus and pathogenic Nigrospora oryzae. The structure of 1, including the absolute configuration, was elucidated by analysis of NMR, HR-ESI-MS data and ECD spectra. Compounds 1, 4 and 6 exhibited significant antifungal activity against Aspergillus fumigatus, with MIC values of 1, 2 and 1 μg/mL, respectively.

PMID:35147448 | DOI:10.1080/14786419.2022.2037589