Discovery of brevijanazines from <em>Aspergillus brevijanus</em> reveals the molecular basis for <em>p</em>-nitrobenzoic acid in fungi

Chem Commun (Camb). 2022 May 10. doi: 10.1039/d2cc01679f. Online ahead of print.

ABSTRACT

The brevijanazines are novel p-nitrobenzoylated piperazines isolated from Aspergillus brevijanus. Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and in vitro microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts p-aminobenzoic acid to p-nitrobenzoic acid.

PMID:35537125 | DOI:10.1039/d2cc01679f