Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus <em>Aspergillus chevalieri</em> MCCC M23426

Front Microbiol. 2022 Jul 7;13:950857. doi: 10.3389/fmicb.2022.950857. eCollection 2022.

ABSTRACT

Two new indole diketopiperazines (1-2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3-11). The structures of 1-2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 57 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC50 value of 4.6 μM.

PMID:35875553 | PMC:PMC9301495 | DOI:10.3389/fmicb.2022.950857

Source: Industry