Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals

Microbes Infect. 2022 Oct 11:105059. doi: 10.1016/j.micinf.2022.105059. Online ahead of print.


The present cross-sectional study aims to explore the fungal community composition of the nasopharyngeal region of SARS-CoV-2 infected individuals and how the infection influences the mycobiome therein. The infection significantly (p<0.05) influenced the alpha diversity. Interestingly, a higher abundance of Cladosporium and Alternaria was noted in the infected individuals and inter-individual variation in mycobiome composition was well supported by beta dispersion analysis (p < 0.05). Moreover, decrease in Aspergillus abundance was observed in infected patients across the four age groups. This study provides insight into the alteration in mycobiome during the viral disease progression and demands continuous investigation to monitor fungal infections.

PMID:36241143 | DOI:10.1016/j.micinf.2022.105059

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