Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
Drug Resist Updat. 2022 Oct 20;65:100885. doi: 10.1016/j.drup.2022.100885. Online ahead of print.
Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.